REAL-TIME VIDEO WATERMARKING FOR COPYRIGHT PROTECTION BASED ON HUMAN PERCEPTION

There is a need for real-time copyright logo insertion in emerging applications, such as Internet protocol television (IPTV). This situation arises in IP-TV and digital TV broadcasting when video residing in a server has to be broadcast by different stations and under different broadcasting rights. Embedded systems that are involved in broadcasting need to have embedded copyright protection. Existing works are targeted towards invisible watermarking, not useful for logo insertion. MPEG-4 is the mainstream exchangeable video format in the Internet today because it has higher and flexible compression rate, lower bit rate, and higher efficiency while superior visual quality.The main steps for MPEG-4 are color space conversion and sampling, DCT and its inverse (IDCT), quantization, zigzag scanning, motion estimation, and entropy coding. In this work a watermarking algorithm that performs the broadcaster\u27s logo insertion as watermark in the DCT domain is been presented. The robustness of DCT watermarking arises from the fact that if an attack tries to remove watermarking at mid frequencies, it will risk degrading the fidelity of the image\video because some perceptive details are at mid frequencies. The suggested methods has implemented in matlab

Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers

Background Gingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by premalignant lesions, including leukoplakia. Previous studies have reported genomic drivers in OSCC, but much remains to be elucidated about DNA methylation patterns across different stages of oral carcinogenesis. Results There is a serious lack of biomarkers and clinical application of biomarkers for early detection and prognosis of gingivobuccal complex cancers. Hence, in search of novel biomarkers, we measured genome-wide DNA methylation in 22 normal oral tissues, 22 leukoplakia, and 74 GBC-OSCC tissue samples. Both leukoplakia and GBC-OSCC had distinct methylation profiles as compared to normal oral tissue samples. Aberrant DNA methylation increases during the different stages of oral carcinogenesis, from premalignant lesions to carcinoma. We identified 846 and 5111 differentially methylated promoters in leukoplakia and GBC-OSCC, respectively, with a sizable fraction shared between the two sets. Further, we identified potential biomarkers from integrative analysis in gingivobuccal complex cancers and validated them in an independent cohort. Integration of genome, epigenome, and transcriptome data revealed candidate genes with gene expression synergistically regulated by copy number and DNA methylation changes. Regularised Cox regression identified 32 genes associated with patient survival. In an independent set of samples, we validated eight genes (FAT1, GLDC, HOXB13, CST7, CYB5A, MLLT11, GHR, LY75) from the integrative analysis and 30 genes from previously published reports. Bisulfite pyrosequencing validated GLDC (P = 0.036), HOXB13 (P < 0.0001) promoter hypermethylation, and FAT1 (P < 0.0001) hypomethylation in GBC-OSCC compared to normal controls. Conclusions Our findings identified methylation signatures associated with leukoplakia and gingivobuccal complex cancers. The integrative analysis in GBC-OSCC identified putative biomarkers that enhance existing knowledge of oral carcinogenesis and may potentially help in risk stratification and prognosis of GBC-OSCC.ISSN:1868-7075ISSN:1868-708